Alpha Lipoic Acid (AlA) Combining with Corticosteroid Hormone Improves the Outcome of Infectious Diseases in Spinal Cord (10 Cases Study)
ثبت نشده
چکیده
Myelitis, Neuromylitis Optica (NMO) and Multiple Sclerosis (MS) are clinic common infectious diseases in spinal cord that are costly, progressive and often cause life-time disabilities. Methylprednisolone Sodium Succinate, a corticosteroid hormone, is a routine effective therapeutic drug for center nerve system (CNS) inflammation, especially applied for MS attacks [1]. However, long term and/or high dose use of corticosteroid hormone has serious side effects such as osteonecrosis of femoral head, cerebral hemorrhage, unstable blood pressure and blood sugar, disorder of kidney [2]. Therefore, corticosteroid hormone therapy is limited on clinical application.
منابع مشابه
The Effect of Exercise Training Intensity and Alpha-Lipoic Acid Supplement on IAPP Gene Expression in the Pancreas in Type 2 Diabetic
Background: The formation of islet amyloid polypeptide (IAPP) have been proposed for d increased b-cell apoptosis in type 2 diabetes. Exercise training plays a protective role against diabetes. Alpha lipoic acid (ALA) is a powerful biological antioxidant. However, the role of exercise training and ALA on IAPP are not well understood. The aim of the present study was to investigate the effect of...
متن کاملComparison of the Effect of Alpha Lipoic Acid (ALA) and Beta-Defensin 1 Protein on Human Sperm Motility and Viability in Different Times of Incubation
Background and Objectives: Antioxidant alpha lipoic acid and β-defensin 1 protein may have a positive effect on the quality of sperm parameters. In this study, the effect of sperm incubation with alpha lipoic acid antioxidant and β-defensin 1 protein were assessed on sperm motility and viability at different times. Methods: In this experimental study, routine semen analysis was carried out o...
متن کاملP-224: The Effect of Alpha Lipoic Acid on ROS Production and TAC Levels of Cultured Isolated Pre-antral Follicles Drived from Mice Vitrified Ovaries
Background: Ovarian cryopreservation is an efficient way to preserve fertility of cancer patients before chemotherapy. This study was designed to evaluate the effect of apha lipoic acid (ALA) on reactive oxygen species (ROS) production and total antioxidant capacity (TAC) of cultured isolated pre-antral follicles derived from vitrified and non-vitrified ovarian tissue. Materials and Methods: Im...
متن کاملMelatonin and Alpha Lipoic Acid: Possible Mitigants for Lopinavir/Ritonavir- Induced Renal Toxicity in Male Albino Rats
Introduction: This study evaluated the effects of pretreatments with melatonin (MT), and Alpha Lipoic acid (ALA) on lopinavir/ritonavir (LPV/r) -induced serum levels of creatinine (Cr), urea (U), uric acid (Ua) and kidney levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT) in male albino rats. Effects of treatments with MT and ALA were also evaluate...
متن کاملEffect of Alpha-lipoic Acid Supplementation on Serum Lipid Profile in Women with Rheumatoid Arthritis
Background and Objectives: Alpha-lipoic acid (ALA) is considered as a potent antioxidant with anti-inflammatory functions. Moreover, a number of studies have revealed its lipid lowering properties. Therefore, we aimed to examine the effect of ALA on serum lipids in women with rheumatoid arthritis (RA), who have high mortality rate mainly due to accelerated atherosclerosis. Materials and Method...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017